I notice that the analog sticks have been moved closer to the sides. Might have been necessary for shorter thumbs trying to reach. The +/- buttons have been moved to the right of the screen. Yeah...what's up with those squares? Maybe they'll be gone for the retail version. They're not labeled.
The good thing for going with the sticks instead of the pads is that they'll be more responsive in shooter games. Plus this allows the sticks to be clickable. Nice move Nintendo.